Exploring the Antihyperlipidemic Properties of Piper nigrum

Humans have used herbal medicine to address medical conditions since the inception of civilization. This study seeks to assess the effectiveness of Piper nigrum as an anti-hyperlipidemic drug and its influence on lipid profiles. We utilized the model to evaluate the effectiveness of the plant antihyperlipidemic activity. SGPT and SGOT levels were statistically significantly reduced (p < 0.05) in groups 6 and 5, respectively, at doses of 900 mg/kg and 600 mg/kg. No groups demonstrated statistically significant results in the renal function test. Despite a slight reduction in total cholesterol, HDL, LDL, and overall cholesterol, no group exhibited statistically significant outcomes. However, the elevated dosage of 900 mg/kg showed the most significant reduction in these metrics. The ethanolic extract of this plant demonstrates significant antihyperlipidemic effects, and further research may aid in the advancement of alternative medical uses.